Guardant Health’s SHIELD data eclipsed by Exact Sciences’ Cologuard comparison

The long-awaited ECLIPSE results for colorectal cancer are finally out. They are positive, but the market reaction has taken opposite directions for the two leading liquid biopsy players, Guardant Health and Exact Sciences (both in our portfolios).

Bottom line

Guardant Health announced positive results for ECLIPSE, a highly anticipated clinical readout evaluating its blood-based test, SHIELD, for the detection of colorectal cancer (CRC). Although the results fell short of investors' expectations, it should not prevent the test from winning FDA approval, guidelines inclusion, and CMS reimbursement.

In our opinion, SHIELD represents a major technological advancement and has the potential to change the CRC screening paradigm by significantly enhancing adherence in the unscreened CRC population. On top of that, as accuracy rapidly improves through AI and data collection, the approach could eventually become the standard of care.

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